Resistance to backup tuberculosis drugs increases

Pulmonary tuberculosis: Resistance pattern to first line anti-tuberculosis drugs

Mycobacterium tuberculosis resistance to antituberculosis drugs in Mozambique*, **

OBJECTIVE To determine the drug resistance profile of Mycobacterium tuberculosis in Mozambique. METHODS We analyzed secondary data from the National Tuberculosis Referral Laboratory, in the city of Maputo, Mozambique, and from the Beira Regional Tuberculosis Referral Laboratory, in the city of Beira, Mozambique. The data were based on culture-positive samples submitted to first-line drug susc...

Primary drug resistance of Mycobacterium tuberculosis to antituberculosis drugs.

Thirty two positive sputa from 104 untreated cases of pulmonary tuberculosis, were tested for sensitivities against antituberculosis drugs. Twenty four were positive on direct smear as well as culture while 8 were only culture positive. Nine (28%) were resistant to Isoniazid, 3 (9.4%) to Streptomycin and 2 (6.3%) were resistant to both the drugs. All the 32 were sensitive to Rifampicin and Etha...

Resistance to second-line drugs in multidrug-resistant tuberculosis.

www.thelancet.com Vol 381 February 23, 2013 625 The lack of participation of India and China, who between them share 50% of the world’s burden of multidrugresistant (MDR) tuberculosis, is a major limitation of the Preserving Eff ective TB Treatment (PETTS) study. Despite this limitation, the fi ndings of the PETTS investigators fi nd great and ominous resonance in India. Second-line drugs are p...

Drug-resistance mechanisms and tuberculosis drugs.

Department of Medicine, Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 0QW, UK (CUK, BJ, SJP, MET); School of Medicine, Tsinghua University, Beijing, China (BJ); Faculty of Law, University of Cambridge, Cambridge, UK (KL); Clinical Microbiology and Public Health Laboratory, Public Health England, Cambridge, UK (MJE, NMB, SJP, MET); Molecular Mycobacteriology, Research Center Bor...